Division of Cancer Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland.
RNA Biol. 2013 Jan;10(1):121-32. doi: 10.4161/rna.23312. Epub 2013 Jan 1.
Members of the DEAD box family of RNA helicases are known to be involved in most cellular processes that require manipulation of RNA structure and, in many cases, exhibit other functions in addition to their established ATP-dependent RNA helicase activities. They thus play critical roles in cellular metabolism and in many cases have been implicated in cellular proliferation and/or neoplastic transformation. These proteins generally act as components of multi-protein complexes; therefore their precise role is likely to be influenced by their interacting partners and to be highly context-dependent. This may also provide an explanation for the sometimes conflicting reports suggesting that DEAD box proteins have both pro- and anti-proliferative roles in cancer.
DEAD 框 RNA 解旋酶家族的成员已知参与大多数需要操纵 RNA 结构的细胞过程，并且在许多情况下，除了其已建立的 ATP 依赖性 RNA 解旋酶活性之外，还具有其他功能。因此，它们在细胞代谢中起着至关重要的作用，并且在许多情况下，它们与细胞增殖和/或肿瘤转化有关。这些蛋白质通常作为多蛋白复合物的组成部分发挥作用；因此，它们的精确作用可能受其相互作用的伙伴影响，并高度依赖于上下文。这也可能解释了有时相互矛盾的报告，即 DEAD 框蛋白在癌症中具有促增殖和抗增殖作用。
