Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC.
Eur J Med Chem. 2013 Apr;62:206-13. doi: 10.1016/j.ejmech.2012.12.038. Epub 2013 Jan 3.
Fructus gardeniae has long been used by traditional Chinese medical practitioners for its anti-inflammatory, anti-oxidant, anti-tumor and anti-hyperlipidemic characteristics. Here we describe our finding that F. gardeniae greatly reduces anti-enterovirus 71 (EV71) activity, resulting in significant decreases in EV71 virus yields, EV71 infections, and internal ribosome entry site activity. We also found that geniposide, a primary F. gardeniae component, inhibited both EV71 replication and viral IRES activity. Our data suggest the presence of a mechanism that blocks viral protein translation. According to our findings, F. gardeniae and geniposide deserve a closer look as potential chemopreventive agents against EV71 infections.
栀子（Fructus Gardeniae）一直以来被中医用于治疗炎症、氧化、肿瘤和高血脂等疾病。在这里，我们发现栀子能显著降低肠道病毒 71 型（EV71）的活性，从而减少 EV71 病毒的产量、感染和内部核糖体进入位点的活性。我们还发现，栀子的主要成分京尼平苷可抑制 EV71 复制和病毒 IRES 活性。我们的数据表明存在一种阻断病毒蛋白翻译的机制。根据我们的发现，栀子和京尼平苷值得进一步研究，作为防治 EV71 感染的潜在化学预防剂。
