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抗病毒三萜类化合物:综述

Anti-viral triterpenes: a review.

作者信息

Darshani Priya, Sen Sarma Shreya, Srivastava Amit K, Baishya Rinku, Kumar Deepak

机构信息

Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Jadavpur, Kolkata, India.

Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Jadavpur, Kolkata, India.

出版信息

Phytochem Rev. 2022;21(6):1761-1842. doi: 10.1007/s11101-022-09808-1. Epub 2022 Mar 5.

Abstract

Triterpenes are naturally occurring derivatives biosynthesized following the isoprene rule of Ruzicka. The triterpenes have been reported to possess a wide range of therapeutic applications including anti-viral properties. In this review, the recent studies (2010-2020) concerning the anti-viral activities of triterpenes have been summarized. The structure activity relationship studies have been described as well as brief biosynthesis of these triterpenes is discussed.

摘要

三萜类化合物是遵循鲁齐卡异戊二烯规则生物合成的天然衍生物。据报道,三萜类化合物具有广泛的治疗应用,包括抗病毒特性。在本综述中,总结了2010年至2020年有关三萜类化合物抗病毒活性的最新研究。还描述了构效关系研究,并讨论了这些三萜类化合物的简要生物合成过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8896976/af95d9b81f1e/11101_2022_9808_Fig1_HTML.jpg

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