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利什曼病中的肿瘤坏死因子（TNFα）。I. TNFα介导宿主对皮肤利什曼病的保护作用。

Tumour necrosis factor (TNF alpha) in leishmaniasis. I. TNF alpha mediates host protection against cutaneous leishmaniasis.

作者信息

Liew F Y, Parkinson C, Millott S, Severn A, Carrier M

机构信息

Department of Experimental Immunology, Wellcome Biotech, Beckenham, Kent, U.K.

出版信息

Immunology. 1990 Apr;69(4):570-3.

PMID:2335376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1385631/
Abstract

Genetically resistant CBA mice developed significantly larger lesions to Leishmania major infection when they were injected with rabbit anti-tumour necrosis factor (TNF)-specific antibodies compared to control mice injected with normal rabbit immunoglobulin. BALB/c mice recovered from a previous infection following prophylactic sublethal irradiation also developed exacerbated lesions when treated with the anti-TNF antibody. Injection of TNF into the lesion of infected CBA mice significantly reduced the lesion development. Furthermore, TNF activates macrophages to kill Leishmania in vitro. These data demonstrate that TNF plays an important role in mediating host-protection against cutaneous leishmaniasis.

摘要

与注射正常兔免疫球蛋白的对照小鼠相比，当注射兔抗肿瘤坏死因子（TNF）特异性抗体时，基因抗性CBA小鼠在感染硕大利什曼原虫后出现的损伤明显更大。先前经亚致死剂量预防性照射后从感染中恢复的BALB/c小鼠在用抗TNF抗体治疗时也出现了加重的损伤。向感染的CBA小鼠损伤部位注射TNF可显著减少损伤的发展。此外，TNF在体外可激活巨噬细胞以杀死利什曼原虫。这些数据表明，TNF在介导宿主对皮肤利什曼病的保护中起重要作用。

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本文引用的文献

1
Purification and physico-chemical characterization of rabbit tumor necrosis factor.兔肿瘤坏死因子的纯化及理化特性分析
J Immunol. 1980 Oct;125(4):1671-7.
2
Immunological regulation of experimental cutaneous leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica.实验性皮肤利什曼病的免疫调节。III. 对热带利什曼原虫高度易感小鼠中细胞介导免疫特异性抑制的性质和意义。
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3
Prophylactic immunization against experimental leishmaniasis. III. Protection against fatal Leishmania tropica infection induced by irradiated promastigotes involves Lyt-1+2- T cells that do not mediate cutaneous DTH.实验性利什曼病的预防性免疫。III. 针对经辐照的前鞭毛体诱导的致命热带利什曼原虫感染的保护作用涉及不介导皮肤迟发型超敏反应的Lyt-1+2- T细胞。
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Production of tumor necrosis factor during murine listeriosis.小鼠李斯特菌病期间肿瘤坏死因子的产生
J Immunol. 1987 Dec 15;139(12):4225-31.
5
Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients.细菌性脑膜炎而非病毒性脑膜炎时脑脊液中的肿瘤坏死因子α。在小鼠模型感染及患者中的评估。
J Exp Med. 1988 May 1;167(5):1743-8. doi: 10.1084/jem.167.5.1743.
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Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria.肿瘤坏死因子（恶病质素）作为鼠脑型疟疾的关键介质。
Science. 1987 Sep 4;237(4819):1210-2. doi: 10.1126/science.3306918.
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Recombinant tumor necrosis factor enhances macrophage destruction of Trypanosoma cruzi in the presence of bacterial endotoxin.在细菌内毒素存在的情况下，重组肿瘤坏死因子可增强巨噬细胞对克氏锥虫的杀伤作用。
J Immunol. 1988 Jul 1;141(1):286-8.
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Endogenous tumor necrosis factor (cachectin) is essential to host resistance against Listeria monocytogenes infection.内源性肿瘤坏死因子（恶病质素）对于宿主抵抗单核细胞增多性李斯特菌感染至关重要。
Infect Immun. 1988 Oct;56(10):2563-9. doi: 10.1128/iai.56.10.2563-2569.1988.
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Autocrine secretion of tumor necrosis factor under the influence of interferon-gamma amplifies HLA-DR gene induction in human monocytes.在γ干扰素影响下肿瘤坏死因子的自分泌可增强人单核细胞中HLA - DR基因的诱导。
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J Immunol. 1987 Nov 15;139(10):3493-6.