Department of Nuclear Medicine, Hôpital Tenon AP-HP, Université Pierre et Marie Curie, Paris, France.
Clin Nucl Med. 2013 Mar;38(3):200-2. doi: 10.1097/RLU.0b013e31827a2294.
The effect of erythropoietin stimulation on bone marrow uptake of FDG has been well documented. Similar metabolic activation of bone marrow with (18)F-fluorocholine (FCH) has not been previously reported. FCH PET/CT was performed in a patient with biochemical recurrent prostate cancer who was receiving erythropoietin for hemochromatosis. Diffuse skeletal uptake of FCH was seen. (18)F-Fluoride PET/CT performed the following day demonstrates multiple abnormal focal bone metastases. Generalized skeletal uptake of FCH results in poor contrast between the metastases compared to noninvolved bone. The metabolic activation of bone marrow by erythropoietin could result in false-negative FCH results for detecting bone metastases.
促红细胞生成素刺激对骨髓摄取 FDG 的影响已有充分的文献记载。（18）F-氟胆碱（FCH）对骨髓的类似代谢激活以前尚未报道过。在一名因血色病接受促红细胞生成素治疗的生化复发性前列腺癌患者中进行了 FCH PET/CT。可见弥漫性骨骼摄取 FCH。（18）F-氟化物 PET/CT 于次日进行，显示多个异常局灶性骨转移。与未受累骨相比，FCH 摄取导致转移灶之间的对比度较差。促红细胞生成素对骨髓的代谢激活可能导致 FCH 检测骨转移的结果出现假阴性。
