Kanazawa Ippei, Sugimoto Toshitsugu
Faculty of Medicine, Shimane University, Japan.
Clin Calcium. 2013 Feb;23(2):181-8.
The fracture risks are increased in patients with lifestyle-related diseases such as diabetes mellitus and dyslipidemia. Bone has been recognized as an endocrine organ to regulate glucose and fat metabolism. Hyperglycemia, advanced glycation end products (AGEs) , and insulin signal are involved in diabetes-related bone disease. Previous studies suggest that hypercholesterolemia may increase the risk of fractures. Adipokines such as leptin and adiponectin derived from fat tissue, which are important regulators for glucose and lipid metabolism, regulate bone metabolism. On the other hand, it has been revealed that osteocalcin, which is secreted from bone tissue into the circulation, has a hormonal function in glucose and fat metabolism.
在患有糖尿病和血脂异常等生活方式相关疾病的患者中，骨折风险会增加。骨骼已被公认为是调节葡萄糖和脂肪代谢的内分泌器官。高血糖、晚期糖基化终产物（AGEs）和胰岛素信号参与了糖尿病相关的骨病。先前的研究表明，高胆固醇血症可能会增加骨折风险。来自脂肪组织的瘦素和脂联素等脂肪因子是葡萄糖和脂质代谢的重要调节因子，它们调节骨代谢。另一方面，已经发现从骨组织分泌到循环中的骨钙素在葡萄糖和脂肪代谢中具有激素功能。
