Kanazawa Ippei
Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
Clin Calcium. 2012 Sep;22(9):1375-82.
Osteocalcin, which is secreted from bone tissue into the circulation, has a hormonal function in glucose metabolism. Previous in vitro and in vivo studies showed that undercarboxylated osteocalcin, but not carboxylated, regulated glucose metabolism by increasing the expression of insulin in pancreatic β cells and adiponectin in adipocytes. Moreover, accumulating clinical studies also indicate that serum osteocalcin level is associated with blood glucose level, parameters of insulin secretion and sensitivity, as well as fat mass. However, it is still unclear whether undercarboxylated osteocalcin is the only one to have the hormonal function in human, or whether interventions for osteoporosis affect glucose metabolism. Therefore, further studies are necessary to clarify these issues.
骨钙素从骨组织分泌进入血液循环，在葡萄糖代谢中发挥激素功能。以往的体外和体内研究表明，未羧化骨钙素而非羧化骨钙素通过增加胰腺β细胞中胰岛素和脂肪细胞中脂联素的表达来调节葡萄糖代谢。此外，越来越多的临床研究也表明，血清骨钙素水平与血糖水平、胰岛素分泌和敏感性参数以及脂肪量有关。然而，尚不清楚未羧化骨钙素是否是人类中唯一具有激素功能的物质，以及骨质疏松症的干预措施是否会影响葡萄糖代谢。因此，有必要进行进一步研究以阐明这些问题。
