Sackner M A, Silva G, Zucker C, Marks M B
Am Rev Respir Dis. 1977 Jun;115(6):945-53. doi: 10.1164/arrd.1977.115.6.945.
Oral metaproterenol was administered daily for 3 months to asthmatic children. The study was designed to determine whether chronic tolerance developed to this drug. Initial and final crossovers on the first 2 and the last 2 days of the investigation to a test dose of metaproterenol and placebo failed to show tolerance as indicated by improvement in lung volumes and dynamic mechanics of breathing after metaproterenol. Forced expiratory volume in 1 sec was the test most consistent in demonstrating bronchodilation; the action of metaproterenol. Forced expiratory volume in 1 sec was the test most consistent in demonstrating bronchodilation; the action of metaproterenol appeared to last at least 5 hours as measured by this test. T of distribution of ventilation, e.g., single- and multiple-breath nitrogen washout tests, were not consistently altered by metaproterenol. These tests did not appear to be sufficiently sensitive to detect improvement even when airway resistance decreased and forced expiratory volume in 1 sec increased toward the normal range.
对哮喘儿童每日给予口服间羟异丙肾上腺素，持续3个月。该研究旨在确定是否会对这种药物产生慢性耐受性。在研究的前2天和最后2天，分别给予间羟异丙肾上腺素试验剂量和安慰剂进行初始和最终交叉试验，结果未显示出耐受性，这可通过间羟异丙肾上腺素给药后肺容量和呼吸动力学的改善来表明。1秒用力呼气量是最能持续证明支气管扩张的检测指标；间羟异丙肾上腺素的作用。1秒用力呼气量是最能持续证明支气管扩张的检测指标；通过该检测指标测量，间羟异丙肾上腺素的作用似乎至少持续5小时。通气分布试验，如单次和多次呼吸氮洗脱试验，并未因间羟异丙肾上腺素而持续改变。即使气道阻力降低且1秒用力呼气量朝着正常范围增加，这些检测指标似乎也不够灵敏，无法检测到改善情况。
