Geumei A M, Miller W F, Miller J, Gast L R
Chest. 1976 Oct;70(4):460-5. doi: 10.1378/chest.70.4.460.
In a single-blind study the short-term effects of oral administration of Th1165a (5, 10, 15, and 20 mg), metaproterenol sulfate (Alupent) (20 mg), and placebo on ventilatory function, pulse rate, and systolic and diastolic blood pressure were compared over a period of six hours in ten patients with stable, reversible obstructive airway disease. Both Th1165a (5, 10, 15 and 20 mg) and metaproterenol administration caused significant bronchodilation of rapid onset (30 minutes), but the bronchodilator effect of Th1165a (10, 15, and 20 mg) was greater and lasted longer (six hours vs three hours) than that of metaproterenol. A dose-dependent bronchodilator effect was recognizable after administration of Th1165a. The 20-mg dose of metaproterenol sulfate and the 5-mg and 10-mg doses of Th1165a produced minimal side effects. Larger doses (15 and 20 mg of Th1165a caused significant increases in pulse rate. Mild and transient tremors were the most common side effect after administration of Th1165a.
在一项单盲研究中，对10例稳定的可逆性阻塞性气道疾病患者口服Th1165a（5、10、15和20毫克）、硫酸间羟异丙肾上腺素（喘舒宁）（20毫克）和安慰剂，比较其在6小时内对通气功能、脉搏率以及收缩压和舒张压的短期影响。Th1165a（5、10、15和20毫克）和硫酸间羟异丙肾上腺素给药均引起快速起效（30分钟）的显著支气管扩张，但Th1165a（10、15和20毫克）的支气管扩张作用比硫酸间羟异丙肾上腺素更大且持续时间更长（6小时对3小时）。给予Th1165a后可观察到剂量依赖性支气管扩张作用。20毫克剂量的硫酸间羟异丙肾上腺素以及5毫克和10毫克剂量的Th1165a产生的副作用最小。较大剂量（15和20毫克的Th1165a）导致脉搏率显著增加。轻度和短暂的震颤是给予Th1165a后最常见的副作用。
