Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Cancer Lett. 2013 Jun 1;333(1):1-8. doi: 10.1016/j.canlet.2013.01.035. Epub 2013 Jan 24.
Pancreatic cancer is one of the most devastating diseases with very poor prognosis. Only a small proportion is curable by surgical resection, whilst standard chemotherapy for patients with advanced disease has only modest effect with substantial toxicity. Therefore, there is an urgent need for the development of novel therapeutic approaches to improve the patient outcome. Recently the viral therapy is emerging as a novel effective therapeutic approach for cancer with the potential to selectively treat both primary tumor and metastatic lesions. This review provides an overview of the current status of viral treatment for pancreatic cancer, both in the laboratories and in clinical settings.
胰腺癌是预后最差的疾病之一。只有一小部分患者可通过手术切除治愈，而晚期患者的标准化疗仅有适度疗效，但毒性较大。因此，迫切需要开发新的治疗方法来改善患者的预后。最近，病毒治疗作为一种治疗癌症的新方法正在兴起，具有选择性治疗原发性肿瘤和转移性病变的潜力。本文综述了病毒治疗胰腺癌的现状，包括实验室和临床研究。
