Özer Erdener, Ünlü Mehtat, Erşen Ayça, Güleklı Bülent
Department of Pathology, Dokuz Eylül University, Faculty of Medicine,İzmir, Turkey.
Turk Patoloji Derg. 2013;29(1):77-9. doi: 10.5146/tjpath.2013.01154.
Chorioamnionitis is most commonly the result of an ascending infection caused by bacteria found within the lower genital tract. Yeast infections causing chorioamnionitis are very uncommon. Candida glabrata is a yeast that is considered to be a commensal of the vagina but vaginitis and rarely upper genital tract infection have been described. We report two cases of fungal chorioamnionitis occurring in pregnancies with a history of in vitro fertilization and cervical cerclage, both resulting in fetal loss. The histological features in conjunction with the positive cultures enabled C. glabrata to be identified as the causative organism producing severe chorioamnionitis. C. glabrata was probably introduced into the cervix at the time of embryo transfer, and during stitching the cervix. To prevent unfavorable outcomes in pregnant women, we recommend that vaginal and in particular cervical swabs should be taken prior to cervical procedures and appropriate treatment should be provided.
绒毛膜羊膜炎最常见的原因是下生殖道细菌上行感染。由酵母菌感染引起的绒毛膜羊膜炎非常罕见。光滑念珠菌是一种酵母菌，被认为是阴道的共生菌，但已有阴道炎及极少的上生殖道感染的报道。我们报告两例发生在有体外受精和宫颈环扎史的妊娠中的真菌性绒毛膜羊膜炎病例，均导致胎儿丢失。组织学特征结合阳性培养结果，使光滑念珠菌被鉴定为引起严重绒毛膜羊膜炎的病原体。光滑念珠菌可能在胚胎移植时及缝合宫颈时被引入宫颈。为防止孕妇出现不良结局，我们建议在进行宫颈手术前应进行阴道拭子检查，尤其是宫颈拭子检查，并给予适当治疗。
