Department of Medicine, Centre of Health Sciences, Regional University of Blumenau, Campus Universitário-Itoupava Seca, 89030-000 Blumenau, SC, Brazil.
Inflammation. 2013 Jun;36(3):729-37. doi: 10.1007/s10753-013-9599-x.
Septic shock is a systemic inflammatory response syndrome, and it is the leading cause of death in intensive care units. Mycophenolate mofetil (MMF) is an immunosuppressant that has been shown to be effective in the treatment of various inflammatory diseases. In this study, the anti-inflammatory effect of MMF in a mouse model of acute lung injury (ALI) induced by lipopolysaccharide (LPS) was evaluated. ALI was induced by intrapleural injection of LPS (250 ng/cavity). The leukocyte migration, exudation, myeloperoxidase and adenosine deaminase activities, nitric oxide products, tumor necrosis factor alpha (TNF-α), and interleukin 1 beta (IL-1β) levels, as well as mRNA expression of TNF-α and IL-1β, were evaluated. This study showed that MMF significantly decreased all parameters studied in a manner comparable to treatment with dexamethasone. In conclusion, MMF has important anti-inflammatory effects that may be useful as an auxiliary treatment for septic shock.
脓毒症休克是一种全身炎症反应综合征，也是重症监护病房死亡的主要原因。霉酚酸酯（MMF）是一种免疫抑制剂，已被证明在治疗各种炎症性疾病方面有效。在这项研究中，评估了 MMF 在脂多糖（LPS）诱导的急性肺损伤（ALI）小鼠模型中的抗炎作用。通过胸腔内注射 LPS（250ng/腔）诱导 ALI。评估白细胞迁移、渗出、髓过氧化物酶和腺苷脱氨酶活性、一氧化氮产物、肿瘤坏死因子-α（TNF-α）和白细胞介素 1β（IL-1β）水平，以及 TNF-α和 IL-1β的 mRNA 表达。这项研究表明，MMF 显著降低了所有研究参数，其方式与地塞米松治疗相当。总之，MMF 具有重要的抗炎作用，可作为脓毒症休克的辅助治疗。
