Oncologist. 2013;18(1):e3-5. doi: 10.1634/theoncologist.2012-0219.
Kinase inhibitors that enter clinical use as treatments for cancer may have off-target effects, making them efficacious in the treatment of autoimmune diseases. Case reports are presented on the potential of erlotinib and gefitinib for treating psoriasis, inflammatory bowel disease, rheumatoid arthritis, and other nonautoimmune inflammatory disorders.
激酶抑制剂作为癌症治疗药物进入临床应用后,可能具有非靶标效应,使其在治疗自身免疫性疾病方面有效。本文报告了厄洛替尼和吉非替尼治疗银屑病、炎症性肠病、类风湿关节炎和其他非自身免疫性炎症性疾病的潜力。