Department of Anatomy and Histology, Collegium Medicum, University of Zielona Gora, Zyty 28, 65-001 Zielona Gora, Poland.
Int J Mol Sci. 2022 Jan 7;23(2):636. doi: 10.3390/ijms23020636.
Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis. Hyperglycemia leads to many serious complications, but also directly initiates the process of β cell apoptosis. A potential strategy for the preservation of pancreatic β cells in diabetes may be to inhibit the implementation of pro-apoptotic pathways or to enhance the action of pancreatic protective factors. The Hippo signaling pathway is proposed and selected as a target to manipulate the activity of its core proteins in therapy-basic research. MST1 and LATS2, as major upstream signaling kinases of the Hippo pathway, are considered as target candidates for pharmacologically induced tissue regeneration and inhibition of apoptosis. Manipulating the activity of components of the Hippo pathway offers a wide range of possibilities, and thus is a potential tool in the treatment of diabetes and the regeneration of β cells. Therefore, it is important to fully understand the processes involved in apoptosis in diabetic states and completely characterize the role of this pathway in diabetes. Therapy consisting of slowing down or stopping the mechanisms of apoptosis may be an important direction of diabetes treatment in the future.
糖尿病是一种病因和发病机制复杂的异质性疾病。高血糖导致许多严重的并发症，但也直接启动了β细胞凋亡的过程。保护糖尿病患者胰岛β细胞的一个潜在策略可能是抑制促凋亡途径的实施，或增强胰腺保护因子的作用。Hippo 信号通路被提出并选择作为操纵其核心蛋白在治疗-基础研究中的活性的靶点。MST1 和 LATS2 作为 Hippo 通路的主要上游信号激酶，被认为是药物诱导组织再生和抑制细胞凋亡的靶候选物。操纵 Hippo 通路的组成部分的活性提供了广泛的可能性，因此是治疗糖尿病和β细胞再生的潜在工具。因此，充分了解糖尿病状态下细胞凋亡涉及的过程，并全面描述该通路在糖尿病中的作用非常重要。减缓或停止细胞凋亡机制的治疗可能是未来糖尿病治疗的一个重要方向。
