Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Biochem Soc Trans. 2013 Feb 1;41(1):79-83. doi: 10.1042/BST20120268.
Ras GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization to influence the spatiotemporal signalling of Ras.
Ras GTPases 是控制增殖、分化和转化途径的重要调节剂。三种广泛表达的几乎相同的 Ras 基因在功能上并非冗余；这归因于它们独特的运输和定位特征。棕榈酰化循环控制 H-Ras 和 N-Ras 的正确区室化。我们回顾了最近的数据，这些数据揭示了这个循环如何通过膜组织的调节来影响 Ras 的时空信号转导。
