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棕榈酰化与外周膜蛋白的运输。

Palmitoylation and the trafficking of peripheral membrane proteins.

机构信息

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.

出版信息

Biochem Soc Trans. 2013 Feb 1;41(1):62-6. doi: 10.1042/BST20120243.

DOI:10.1042/BST20120243
PMID:23356259
Abstract

Palmitoylation, the attachment of palmitate and other fatty acids on to cysteine residues, is a common post-translational modification of both integral and peripheral membrane proteins. Dynamic palmitoylation controls the intracellular distribution of peripheral membrane proteins by regulating membrane-cytosol exchange and/or by modifying the flux of the proteins through vesicular transport systems.

摘要

棕榈酰化,即棕榈酸和其他脂肪酸与半胱氨酸残基的连接,是整合膜蛋白和外周膜蛋白的常见翻译后修饰。动态棕榈酰化通过调节膜-细胞质交换和/或通过改变蛋白质通过囊泡运输系统的通量来控制外周膜蛋白的细胞内分布。

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