通过 1,3-二炔的 Cope 型氢胺化反应合成 3,5-二取代吡唑。
Synthesis of 3,5-disubstituted pyrazoles via Cope-type hydroamination of 1,3-dialkynes.
机构信息
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.
出版信息
J Org Chem. 2013 Feb 15;78(4):1693-8. doi: 10.1021/jo302732v. Epub 2013 Feb 6.
PMID:23356512
Abstract
An efficient method for the synthesis of 3,5-disubstituted pyrazoles is described. The reactions of 1,3-dialkynes with hydrazine proceeded smoothly in dimethyl sulfoxide under mild reaction conditions to produce 3,5-disubstituted pyrazoles in satisfactory to excellent yields. A one-pot procedure of the transformation has been developed.
摘要
描述了一种合成 3,5-二取代吡唑的有效方法。在温和的反应条件下，1,3-二炔与水合肼在二甲亚砜中反应顺利，以令人满意至优秀的收率得到 3,5-二取代吡唑。已经开发出一种一锅法转化程序。
Zotero 插件