Department of Internal Medicine, University at Buffalo, Buffalo, NY 14215, USA.
Ren Fail. 2013;35(3):333-7. doi: 10.3109/0886022X.2012.757824. Epub 2013 Jan 29.
Glomerular filtration rate (GFR) is an essential clinical assessment of renal function post-renal transplantation. Creatinine clearance (CrCl) measured over 12 h and estimated GFR (e-GFR) (calculated by the Modification of diet in renal disease equation) were compared in 28 stable renal transplant recipients (RTRs). This single center study included 14 African American (AA) and 14 Caucasian (CC) recipients. The 12-h creatinine clearance (CrCl-12 h) was determined by monitored urine collection and by e-GFR on two occasions (two phases) separated by at least 2 weeks. Statistics included mixed model analysis of CrCl-12 h and e-GFR relative to race, phase, and difference between parameters. In the first phase, the e-GFR was higher in AA males (58.4 ± 14.8 mL/min) than the CC males (46.2 ± 10.2 mL/min) (p = 0.032), whereas the CrCl-12 h of AA males (70.8 ± 8.7 mL/min) and CC males (63.3 ± 21.7 mL/min) was not different (p = 0.740). During the second phase, the e-GFR in AA and CC RTRs was 55.4 ± 10.1 mL/min and 47.6 ± 10.7 mL/min (p = 0.117), respectively, whereas CrCl-12 h in AAs was 64.71 ± 17.9 mL/min and in CCs was 62.0 ± 14.9 mL/min (p = 1.000). The CrCl-12 h was higher than the e-GFR (p < 0.001) irrespective of race or phase. CrCl-12 h was not different on both occasions (p = 0.289) in all the patients. CrCl-12 h was consistently greater than e-GFR. The difference between these e-GFR estimates may have an importance in the care of RTRs.
肾小球滤过率（GFR）是肾移植后评估肾功能的重要临床指标。本研究对 28 例稳定的肾移植受者（RTR）进行了 12 小时肌酐清除率（CrCl-12 h）和估算肾小球滤过率（e-GFR）（通过肾脏病饮食改良公式计算）的比较。该单中心研究包括 14 例非裔美国人（AA）和 14 例白种人（CC）受者。12 小时肌酐清除率（CrCl-12 h）通过监测尿液收集和两次 e-GFR 检测（两个阶段）来确定，两次检测至少间隔 2 周。统计学分析包括混合模型分析 CrCl-12 h 和 e-GFR 与种族、阶段和参数差异的关系。在第一阶段，AA 男性的 e-GFR（58.4 ± 14.8 mL/min）高于 CC 男性（46.2 ± 10.2 mL/min）（p = 0.032），而 AA 男性（70.8 ± 8.7 mL/min）和 CC 男性（63.3 ± 21.7 mL/min）的 CrCl-12 h 无差异（p = 0.740）。在第二阶段，AA 和 CC RTRs 的 e-GFR 分别为 55.4 ± 10.1 mL/min 和 47.6 ± 10.7 mL/min（p = 0.117），而 AA 的 CrCl-12 h 为 64.71 ± 17.9 mL/min，CC 为 62.0 ± 14.9 mL/min（p = 1.000）。CrCl-12 h 高于 e-GFR（p < 0.001），无论种族或阶段如何。所有患者两次检测的 CrCl-12 h 无差异（p = 0.289）。CrCl-12 h 始终大于 e-GFR。这些 e-GFR 估计值之间的差异可能对 RTR 的护理具有重要意义。
