Lu Liang, Li Dong, He Fu-Chu
Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China.
Yi Chuan. 2013 Jan;35(1):17-26. doi: 10.3724/sp.j.1005.2013.00017.
Ubiquitin-proteasome system (UPS) mediates 80% to 85% of the protein degradation in eukaryotic cells. The characteristics of UPS pathway are dependent on ATP, efficient and highly selective. Ubiquitination not only participates in protein degradation, but also directly affects protein activity and localization. Ubiquitination can regulate multiple cellular processes including cell cycle progression, apoptosis, transcriptional regulation, DNA damage repair and immune response. More and more datasets about UPS are published, and it is necessary to organize and analyze these data efficiently. We re-view the related bioinformatics studies in UPS datasets, such as collection of UPS related proteins, construction and analysis of ubiquitination networks, prediction of ubiquitination sites and motifs. Some potential perspectives are also discussed.
泛素-蛋白酶体系统（UPS）介导真核细胞中80%至85%的蛋白质降解。UPS途径的特点是依赖ATP、高效且具有高度选择性。泛素化不仅参与蛋白质降解，还直接影响蛋白质活性和定位。泛素化可调节多种细胞过程，包括细胞周期进程、细胞凋亡、转录调控、DNA损伤修复和免疫反应。越来越多关于UPS的数据集被发表，因此有必要对这些数据进行高效的组织和分析。我们回顾了UPS数据集中的相关生物信息学研究，如UPS相关蛋白的收集、泛素化网络的构建与分析、泛素化位点和基序的预测。还讨论了一些潜在的观点。
