Kim Seok Hwan, Jeoung Jin Wook, Park Ki Ho, Kim Tae-Woo, Kim Dong Myung
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
Ophthalmic Surg Lasers Imaging. 2012 Nov-Dec;43(6 Suppl):S75-82. doi: 10.3928/15428877-20121001-01.
To identify the correlation between retinal nerve fiber layer (RNFL) thickness and visual field sensitivity in healthy eyes with preperimetric and perimetric glaucoma and to estimate the functional RNFL loss in eyes with pre-perimetric glaucoma.
One hundred and two eyes with glaucoma and diffuse RNFL atrophy and 102 healthy eyes were enrolled. The correlation between optical coherence tomography (OCT)-measured RNFL thickness of the superior (clock-hour segments 10, 11, 12, 1, 2, and 3) and inferior (clock-hour segments 5, 6, 7, and 8) area and the average total deviations of the inferior and superior hemifields in standard automated perimetry (SAP) were evaluated using the simple linear model, respectively. The OCT-measured RNFL thickness was assumed to comprise functional and residual thicknesses; the residual thickness was calculated from the simple linear model and the eyes with severe diffuse RNFL atrophy. Functional RNFL thickness was compared between groups.
Twenty-seven eyes had preperimetric and 75 eyes had perimetric glaucoma. The coefficient of determination (R(2)) of the simple linear model was 0.71 to 0.77 for the correlation between RNFL thickness and total deviation of SAP. The estimated residual thickness was 50.4 to 56.5 μm. On comparison with normal eyes, eyes with preperimetric glaucoma were estimated to have 37% to 41% functional RNFL loss.
The correlation between RNFL thickness and SAP sensitivity was well explained by the simple linear model. Approximately 40% loss of the functional RNFL was found in preperimetric glaucoma.
确定青光眼视野检查前期和视野检查期健康眼中视网膜神经纤维层（RNFL）厚度与视野敏感度之间的相关性，并评估青光眼视野检查前期眼中功能性RNFL的损失情况。
纳入102例患有青光眼且伴有弥漫性RNFL萎缩的患者以及102例健康受试者。分别采用简单线性模型评估光学相干断层扫描（OCT）测量的上方（钟点数10、11、12、1、2和3区域）和下方（钟点数5、6、7和8区域）RNFL厚度与标准自动视野计（SAP）中下方和上方半视野平均总偏差之间的相关性。假设OCT测量的RNFL厚度由功能性厚度和残余厚度组成；残余厚度通过简单线性模型和患有严重弥漫性RNFL萎缩的眼睛计算得出。比较各组之间的功能性RNFL厚度。
27只眼处于青光眼视野检查前期，75只眼处于青光眼视野检查期。简单线性模型的决定系数（R²）显示，RNFL厚度与SAP总偏差之间的相关性为0.71至0.77。估计的残余厚度为50.4至56.5μm。与正常眼相比，青光眼视野检查前期的眼睛估计有37%至41%的功能性RNFL损失。
简单线性模型很好地解释了RNFL厚度与SAP敏感度之间的相关性。在青光眼视野检查前期发现约40%的功能性RNFL损失。
