Sugimoto M, Araki S
First Department of Internal Medicine, Kumamoto University Medical School, Japan.
Kansenshogaku Zasshi. 1990 Jan;64(1):12-8. doi: 10.11150/kansenshogakuzasshi1970.64.12.
Patients with HTLV-I-associated myelopathy (HAM) show subclinical pulmonary involvement. Bronchoalveolar lavage (BAL) studies of HAM patients have shown that there is T-lymphocytosis in association with increased soluble IL-2 receptor levels in BAL fluid. Furthermore, BAL lymphocytes as well as peripheral blood lymphocytes obtained from HAM patients proliferated spontaneously when cultured in vitro. The lymphocytes proliferating were T-lymphocytes (both CD4+ cells and CD8+ cells) and released soluble IL-2 receptors in supernatant fluid. These results indicated that T-lymphocytes were activated in HAM patients. In conclusion, activated T-lymphocytes may play an important role in the development of the spinal cord and pulmonary lesions in HAM patients.
成人T细胞白血病病毒I型相关脊髓病（HAM）患者存在亚临床肺部受累情况。对HAM患者进行的支气管肺泡灌洗（BAL）研究表明，BAL液中存在T淋巴细胞增多，同时可溶性白细胞介素-2受体水平升高。此外，从HAM患者获取的BAL淋巴细胞以及外周血淋巴细胞在体外培养时会自发增殖。增殖的淋巴细胞为T淋巴细胞（包括CD4+细胞和CD8+细胞），并在上清液中释放可溶性白细胞介素-2受体。这些结果表明HAM患者体内的T淋巴细胞被激活。总之，激活的T淋巴细胞可能在HAM患者脊髓和肺部病变的发展中起重要作用。
