Neurophysics Group, State University of Campinas, Brazil.
Epilepsy Behav. 2013 Apr;27(1):22-8. doi: 10.1016/j.yebeh.2012.12.009. Epub 2013 Jan 28.
BACKGROUND/PURPOSE: Juvenile myoclonic epilepsy (JME) is the most frequent subsyndrome of the idiopathic generalized epilepsies, and experimental investigations support that the thalamus is a key structure in the mechanisms of JME. Texture analysis (TA) is an image processing technique which can be used to characterize images such as MRI.
The goal of this work was to investigate the thalamus of patients with JME using TA, a quantitative neuroimaging technique.
Patients and controls were submitted to MRI investigation. Images were acquired in a 2-Tesla scanner. The T1 volumetric sequence was used for thalamic segmentation and extraction of texture parameters. Twenty-four patients with a diagnosis of JME and 20 healthy volunteers were investigated.
Texture analysis revealed differences between the right thalamus of patients and controls.
The present investigation supports the participation of the thalamus in the disease mechanisms of JME. Texture analysis may be a useful tool in the quantitative neuroimaging investigation of the epilepsies and can be important to understand JME.
背景/目的：青少年肌阵挛癫痫（JME）是特发性全面性癫痫中最常见的亚型，实验研究支持丘脑是 JME 机制中的关键结构。纹理分析（TA）是一种图像处理技术，可用于描述 MRI 等图像。
本工作旨在使用 TA（一种定量神经影像学技术）研究 JME 患者的丘脑。
患者和对照组均接受 MRI 检查。图像在 2T 扫描仪上采集。T1 容积序列用于丘脑分割和提取纹理参数。研究了 24 例 JME 诊断患者和 20 名健康志愿者。
纹理分析显示患者和对照组右侧丘脑存在差异。
本研究支持丘脑参与 JME 的疾病机制。纹理分析可能是癫痫定量神经影像学研究的有用工具，对于理解 JME 很重要。
