Brain Morphometry Laboratory, Epilepsy Programme, Beaumont Hospital, Dublin, Ireland.
Epilepsia. 2013 Sep;54(9):e138-41. doi: 10.1111/epi.12330. Epub 2013 Aug 14.
The goal of this study was to characterize cerebral cortex thickness patterns in juvenile myoclonic epilepsy (JME). Surface-based morphometry (SBM) was applied to process brain magnetic resonance images acquired from 24 patients with JME and 40 healthy controls and quantify cerebral cortex thickness. Differences in cortical thickness between patients and controls were determined using generalized linear model (covariates: age and gender). In patients with JME, thickness increase was detected bilaterally within localized regions in the orbitofrontal and mesial frontal cortices. Such thickness patterns coexisted with significant bilateral reduction in thalamic volume. These findings confirm that the underlying mechanisms in JME are related to aberrant corticothalamic structure and indicate that frontal cortex abnormalities are possibly linked to regional increase in cerebral cortical thickness.
本研究旨在描述青少年肌阵挛癫痫（JME）患者大脑皮层厚度的变化模式。我们采用基于表面的形态计量学（SBM）方法对 24 例 JME 患者和 40 名健康对照者的脑部磁共振成像进行处理，以定量测量大脑皮层厚度。使用广义线性模型（协变量：年龄和性别）确定患者和对照组之间的皮质厚度差异。在 JME 患者中，双侧眶额皮质和内侧额皮质的局部区域存在皮质厚度增加。这些厚度变化模式与丘脑体积的显著双侧减小共存。这些发现证实 JME 的潜在机制与皮质丘脑结构异常有关，并表明额叶皮层异常可能与大脑皮层厚度的区域性增加有关。
