Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Virology. 2013 Mar 30;438(1):1-4. doi: 10.1016/j.virol.2012.12.016. Epub 2013 Jan 26.
MicroRNAs upregulated during CD4(+) T cell activation may contribute to the increased efficiency of HIV-1 replication seen following perturbation of the resting state. We have found miR-132 to be highly upregulated following CD4(+) T cell activation, and show that miR-132 potentiates viral replication in the Jurkat CD4(+) T cell line. Knockdown of MeCP2, a previously identified target of miR-132, also increases HIV-1 replication. To the best of our knowledge, miR-132 is the first miRNA reported to enhance HIV-1 replication.
在 CD4(+) T 细胞激活过程中上调的 microRNAs 可能有助于在扰乱静息状态后增加 HIV-1 复制的效率。我们发现 miR-132 在 CD4(+) T 细胞激活后高度上调，并表明 miR-132 增强了 Jurkat CD4(+) T 细胞系中的病毒复制。先前鉴定的 miR-132 的靶标 MeCP2 的敲低也增加了 HIV-1 的复制。据我们所知，miR-132 是第一个被报道增强 HIV-1 复制的 microRNA。
