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关于微小RNA与病毒发病机制及感染之间相互作用的全面综述。

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection.

作者信息

Bahojb Mahdavi Seyedeh Zahra, Jebelli Asiyeh, Aghbash Parisa Shiri, Baradaran Behzad, Amini Mohammad, Oroojalian Fatemeh, Pouladi Nasser, Baghi Hossein Bannazadeh, de la Guardia Miguel, Mokhtarzadeh Amir Ali

机构信息

Department of Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Med Res Rev. 2025 Mar;45(2):349-425. doi: 10.1002/med.22073. Epub 2024 Aug 26.

DOI:10.1002/med.22073
PMID:39185567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11796338/
Abstract

Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral infections. They can promote or inhibit viral infection and have a pro-viral or antiviral role. Also, viral infections can modulate the expression of host miRNAs. Furthermore, viruses from different families evade the host immune response by producing their own miRNAs called viral miRNAs (v-miRNAs). Understanding the replication cycle of viruses and their relation with host miRNAs and v-miRNAs can help to find new treatments against viral infections. In this review, we aim to outline the structure, genome, and replication cycle of various viruses including hepatitis B, hepatitis C, influenza A virus, coronavirus, human immunodeficiency virus, human papillomavirus, herpes simplex virus, Epstein-Barr virus, Dengue virus, Zika virus, and Ebola virus. We also discuss the role of different host miRNAs and v-miRNAs and their role in the pathogenesis of these viral infections.

摘要

病毒作为最小的感染因子所引发的感染，对全球公共卫生构成重大威胁。病毒感染利用不同的宿主机制来促进自身的传播和发病机制。微小RNA（miRNA）作为小的非编码RNA分子，在包括病毒感染在内的不同疾病中发挥重要的调节作用。它们可以促进或抑制病毒感染，具有促病毒或抗病毒作用。此外，病毒感染可以调节宿主miRNA的表达。此外，来自不同家族的病毒通过产生自身的miRNA（称为病毒miRNA，v-miRNA）来逃避宿主免疫反应。了解病毒的复制周期及其与宿主miRNA和v-miRNA的关系有助于找到针对病毒感染的新治疗方法。在这篇综述中，我们旨在概述各种病毒的结构、基因组和复制周期，包括乙型肝炎病毒、丙型肝炎病毒、甲型流感病毒、冠状病毒、人类免疫缺陷病毒、人乳头瘤病毒、单纯疱疹病毒、爱泼斯坦-巴尔病毒、登革热病毒、寨卡病毒和埃博拉病毒。我们还将讨论不同宿主miRNA和v-miRNA的作用及其在这些病毒感染发病机制中的作用。

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