Department of Virology, Haartman Institute, P.O. Box 21, FI-00014, University of Helsinki, Finland.
Virology. 2013 Mar 15;437(2):73-80. doi: 10.1016/j.virol.2013.01.001. Epub 2013 Jan 26.
Viruses of the family Bunyaviridae are negative-sense RNA viruses (NRVs). Unlike other NRVs bunyaviruses do not possess a matrix protein, which typically facilitates virus release from host cells and acts as an anchor between the viral membrane and its genetic core. Therefore the functions of matrix protein in bunyaviruses need to be executed by other viral proteins. In fact, the cytoplasmic tail of glycoprotein Gn (Gn-CT) of various bunyaviruses interacts with the genetic core (nucleocapsid protein and/or genomic RNA). In addition the Gn-CT of phleboviruses (a genus in the family Bunyaviridae) has been demonstrated to be essential for budding. This review brings together what is known on the role of various bunyavirus Gn-CTs in budding and assembly, and hypothesizes on their yet unrevealed functions in viral life cycle by comparing to the matrix proteins of NRVs.
布尼亚病毒科的病毒为负义 RNA 病毒 (NRVs)。与其他 NRVs 不同，布尼亚病毒不具有基质蛋白，该蛋白通常有助于病毒从宿主细胞中释放，并充当病毒膜与其遗传核心之间的连接物。因此，基质蛋白在布尼亚病毒中的功能需要由其他病毒蛋白来执行。事实上，各种布尼亚病毒糖蛋白 Gn 的细胞质尾巴 (Gn-CT) 与遗传核心 (核衣壳蛋白和/或基因组 RNA) 相互作用。此外，已证实噬肺病毒（布尼亚病毒科的一个属）的 Gn-CT 对于出芽是必需的。本综述汇集了关于各种布尼亚病毒 Gn-CT 在出芽和组装中的作用的已知信息，并通过与 NRVs 的基质蛋白进行比较，推测了它们在病毒生命周期中尚未揭示的功能。
