Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional del IPN Unidad Durango, Academia de Genómica, CIIDIR-IPN, Durango, México.
Pharmacogenomics J. 2013 Dec;13(6):567-72. doi: 10.1038/tpj.2012.52. Epub 2013 Jan 29.
We previously documented the lowest frequency of CYP2C92 in Mexican indigenous Tepehuanos followed by Mestizos and Mexican-Americans populations, suggesting a negative correlation between the CYP2C92 frequency and the degree of Asian ancestry in indigenous Americans. We determined the influence of ethnic admixture components on the CYP2C9 allele distribution in 505 Amerindian from eight indigenous populations through genotyping CYP2C92, 3 and 6 alleles by real-time PCR and molecular evaluation of ancestry. The frequencies for CYP2C92 were 0.026 in Seris and 0.057 in Mayos, being higher than in Asians (P<0.001). CYP2C93 was found in Tarahumaras (0.104), Mayos (0.091), Tepehuanos (0.075), Guarijíos (0.067), Huicholes (0.033) and Coras (0.037), with East Asians having lower frequencies than the former three groups (P<0.001). CYP2C96 was not found. The frequency of CYP2C9*2 was lower in Amerindians than in European populations, and higher than their Asian ancestors. The presence of this allele in ethnic groups in Mexico can be explained by European admixture.
我们之前记录了墨西哥本土特佩万诺人的 CYP2C92 频率最低，其次是梅斯蒂索人和墨西哥裔美国人，这表明 CYP2C92 频率与美洲原住民中亚裔血统的程度呈负相关。我们通过实时 PCR 对 CYP2C92、3 和6 等位基因进行基因分型，并通过对祖先的分子评估，确定了种族混合成分对 505 名来自 8 个原住民群体的美洲印第安人 CYP2C9 等位基因分布的影响。CYP2C92 的频率在 Seris 为 0.026，在 Mayo 为 0.057，高于亚洲人（P<0.001）。Tarahumaras（0.104）、Mayos（0.091）、Tepehuanos（0.075）、Guarijíos（0.067）、Huicholes（0.033）和 Coras（0.037）中发现了 CYP2C93，东亚人的频率低于前三个群体（P<0.001）。未发现 CYP2C96。美洲印第安人的 CYP2C9*2 频率低于欧洲人群，高于其亚洲祖先。该等位基因在墨西哥的族群中存在，可以用欧洲人的混合来解释。
