慢性淋巴细胞白血病中的调节性T细胞：是参与者还是无辜旁观者？
Regulatory T-cells in chronic lymphocytic leukemia: actor or innocent bystander?
作者信息
D'Arena Giovanni, Simeon Vittorio, D'Auria Fiorella, Statuto Teodora, Sanzo Paola Di, Martino Laura De, Marandino Aurelio, Sangiorgio Michele, Musto Pellegrino, Feo Vincenzo De
机构信息
Onco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata Rionero in Vulture, Italy.
出版信息
Am J Blood Res. 2013;3(1):52-7. Epub 2013 Jan 17.
Abstract
Regulatory T (Treg) cells are now under extensive investigation in chronic lymphocytic leukemia (CLL). This small subset of T-cells has been, in fact, considered to be involved in the pathogenesis and progression of CLL. However, whether Treg dysregulation in CLL plays a key role or it rather represents a simple epiphenomenon is still matter of debate. In the former case, Treg cells could be appealing for targeting therapies. Finally, Treg cells have also been proposed as a prognostic indicator of the disease clinical course.
摘要
调节性T（Treg）细胞目前正在慢性淋巴细胞白血病（CLL）中接受广泛研究。事实上，这一T细胞小亚群已被认为参与了CLL的发病机制和进展。然而，CLL中Treg细胞失调是发挥关键作用还是仅仅代表一种简单的附带现象仍存在争议。在前一种情况下，Treg细胞可能成为靶向治疗的有吸引力的靶点。最后，Treg细胞也被提议作为该疾病临床病程的一个预后指标。
相似文献
1
Regulatory T-cells in chronic lymphocytic leukemia: actor or innocent bystander?
Am J Blood Res. 2013;3(1):52-7. Epub 2013 Jan 17.
2
CD4CD25CD127FoxP Regulatory T Cell Subpopulations in the Bone Marrow and Peripheral Blood of Children with ALL: Brief Report.
J Immunol Res. 2018 May 29;2018:1292404. doi: 10.1155/2018/1292404. eCollection 2018.
3
Increased IL-10/IL-17 ratio is aggravated along with the prognosis of patients with chronic lymphocytic leukemia.
Int Immunopharmacol. 2016 Nov;40:57-64. doi: 10.1016/j.intimp.2016.07.008. Epub 2016 Aug 29.
4
Regulatory T-cells in B-cell chronic lymphocytic leukemia: their role in disease progression and autoimmune cytopenias.
Leuk Lymphoma. 2013 May;54(5):1012-9. doi: 10.3109/10428194.2012.728287. Epub 2012 Oct 16.
5
A matter of debate in chronic lymphocytic leukemia: is the occurrence of autoimmune disorders an indicator of chronic lymphocytic leukemia therapy?
Curr Opin Oncol. 2011 Sep;23(5):455-60. doi: 10.1097/CCO.0b013e328348c683.
6
Regulatory T-cell and T-helper 17 balance in chronic lymphocytic leukemia progression and autoimmune cytopenias.
Leuk Lymphoma. 2015;56(8):2424-8. doi: 10.3109/10428194.2014.986479. Epub 2015 Jan 21.
7
A study for proposal of use of regulatory T cells as a prognostic marker and establishing an optimal threshold level for their expression in chronic lymphocytic leukemia.
Leuk Lymphoma. 2015 Jun;56(6):1831-8. doi: 10.3109/10428194.2014.966245. Epub 2014 Oct 28.
8
Characterization of regulatory T cells in patients with B-cell chronic lymphocytic leukemia.
Oncol Rep. 2008 Sep;20(3):677-82.
9
Circulating regulatory T cells in "clinical" monoclonal B-cell lymphocytosis.
Int J Immunopathol Pharmacol. 2011 Oct-Dec;24(4):915-23. doi: 10.1177/039463201102400410.
10
Quantitative and qualitative analysis of regulatory T cells in B cell chronic lymphocytic leukemia.
Leuk Res. 2017 Sep;60:74-81. doi: 10.1016/j.leukres.2017.07.004. Epub 2017 Jul 25.
引用本文的文献
1
Immunophenotyping of Peripheral Blood Cells in Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib.
Cells. 2024 Aug 30;13(17):1458. doi: 10.3390/cells13171458.
2
Transcriptome profiling of regulatory T cells from children with transient hypogammaglobulinemia of infancy.
Clin Exp Immunol. 2023 Dec 13;214(3):275-288. doi: 10.1093/cei/uxad116.
3
New Flow Cytometric Methods for Monitoring STAT5 Signaling Reveal Responses to SARS-CoV-2 Antigen-Specific Stimulation in FOXP3+ Regulatory T Cells also in Patients with Advanced Chronic Lymphocytic Leukemia.
Biosensors (Basel). 2023 May 11;13(5):539. doi: 10.3390/bios13050539.
4
The role of Th17 cells in chronic lymphocytic leukemia: friend or foe?
Blood Adv. 2023 Jun 13;7(11):2401-2417. doi: 10.1182/bloodadvances.2022008985.
5
A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia.
Front Immunol. 2022 Feb 28;13:781364. doi: 10.3389/fimmu.2022.781364. eCollection 2022.
6
Does physical exercise improve or deteriorate treatment of multiple sclerosis with mitoxantrone? Experimental autoimmune encephalomyelitis study in rats.
BMC Neurosci. 2022 Mar 5;23(1):11. doi: 10.1186/s12868-022-00692-1.
7
Revisiting Autoimmunity in Chronic Lymphocytic Leukemia: Prognostic Value of Positive Direct Antiglobulin Test in a Retrospective Study and Literature Review.
J Blood Med. 2021 Apr 13;12:225-234. doi: 10.2147/JBM.S296225. eCollection 2021.
8
T-cells in chronic lymphocytic leukemia: Guardians or drivers of disease?
Leukemia. 2020 Aug;34(8):2012-2024. doi: 10.1038/s41375-020-0873-2. Epub 2020 May 26.
9
PI3Kδ inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia.
Leukemia. 2019 Jun;33(6):1427-1438. doi: 10.1038/s41375-018-0318-3. Epub 2018 Dec 20.
10
Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients.
J Transl Med. 2018 Jun 20;16(1):172. doi: 10.1186/s12967-018-1545-0.
本文引用的文献
1
Regulatory T-cells in B-cell chronic lymphocytic leukemia: their role in disease progression and autoimmune cytopenias.
Leuk Lymphoma. 2013 May;54(5):1012-9. doi: 10.3109/10428194.2012.728287. Epub 2012 Oct 16.
2
Regulatory T-cells in chronic lymphocytic leukemia and autoimmune diseases.
Mediterr J Hematol Infect Dis. 2012;4(1):e2012053. doi: 10.4084/MJHID.2012.053. Epub 2012 Aug 9.
3
Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer.
Oncoimmunology. 2012 May 1;1(3):326-333. doi: 10.4161/onci.18852.
4
A shorter time to the first treatment may be predicted by the absolute number of regulatory T-cells in patients with Rai stage 0 chronic lymphocytic leukemia.
Am J Hematol. 2012 Jun;87(6):628-31. doi: 10.1002/ajh.23170. Epub 2012 Mar 28.
5
Circulating regulatory T cells in "clinical" monoclonal B-cell lymphocytosis.
Int J Immunopathol Pharmacol. 2011 Oct-Dec;24(4):915-23. doi: 10.1177/039463201102400410.
6
Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia.
Mod Pathol. 2012 Feb;25(2):246-59. doi: 10.1038/modpathol.2011.164. Epub 2011 Nov 18.
7
Chronic lymphocytic leukaemia cells drive the global CD4+ T cell repertoire towards a regulatory phenotype and leads to the accumulation of CD4+ forkhead box P3+ T cells.
Clin Exp Immunol. 2011 Nov;166(2):154-63. doi: 10.1111/j.1365-2249.2011.04466.x.
8
Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia.
Cancer. 2011 Sep 1;117(17):3999-4008. doi: 10.1002/cncr.25983. Epub 2011 Feb 24.
9
Targeting regulatory T cells for anticancer therapy.
Mini Rev Med Chem. 2011 Jun;11(6):480-5. doi: 10.2174/138955711795843365.
10
Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia.
Cancer. 2011 May 15;117(10):2163-9. doi: 10.1002/cncr.25752. Epub 2010 Nov 18.
Zotero 插件