Ghazi Ali A, Boustani Iranpour, Amouzegar Atieh, Attarian Hamid, Pourafkari Marina, Gashti Hossein Nejad, Sabetian Taher, Tirgari Farrokh, Ghazi Siavash, Kovacs Kalman
Research Institute for Endocrine Sciences, Taleghani General Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Med Sci. 2011 Sep;36(3):217-21.
Parathyroid hormone-related protein producing pancreatic neuroendocrine tumors have been infrequently reported. Herein, we report a case of an Iranian woman who had such a tumor during pregnancy, and gave birth to a female neonate with esophago-tracheal fistula and imperforated anus. Hypercalcemia was diagnosed at postpartum because of elevated serum calcium levels in the neonate and neurologic deterioration of the mother. Extensive literature review revealed 42 cases with pancreatic neuroendocrine tumors and hypercalcaemia. The clinical and laboratory findings of such patients are reviewed in this manuscript.
产生甲状旁腺激素相关蛋白的胰腺神经内分泌肿瘤鲜有报道。在此,我们报告一例伊朗女性病例,该女性在孕期患有此类肿瘤,并产下一名患有食管气管瘘和肛门闭锁的女婴。产后,由于新生儿血清钙水平升高以及母亲的神经功能恶化,诊断出高钙血症。广泛的文献综述显示有42例胰腺神经内分泌肿瘤合并高钙血症的病例。本文对这些患者的临床和实验室检查结果进行了综述。