铜-N-杂环卡宾配合物促进的 2-萘酚的杂偶联反应。
Heterocoupling of 2-naphthols enabled by a copper-N-heterocyclic carbene complex.
机构信息
Département de Chimie, Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7.
出版信息
Chem Commun (Camb). 2013 Mar 4;49(18):1835-7. doi: 10.1039/c3cc38675a. Epub 2013 Jan 28.
PMID:23358599
Abstract
The reactivity of a Cu catalyst for oxidative coupling is modulated by a small molecule additive, diethyl malonate, that slows over-oxidation of 2-naphthols. Efficient heterocoupling between electron-rich and electron-poor 2-naphthols/2-naphthylamines affords C(1)-symmetric BINOLs with yields ranging from 35-98%.
摘要
小分子添加剂二乙酯丙二酸酯调节 Cu 催化剂的氧化偶联反应活性，减缓 2-萘酚的过度氧化。富电子和缺电子的 2-萘酚/2-萘基胺之间的高效杂偶联反应以 35-98%的收率得到 C(1)对称的联二萘酚。
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