Department of Mathematical Sciences, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA.
Bull Math Biol. 2013 Mar;75(3):393-427. doi: 10.1007/s11538-013-9810-0. Epub 2013 Jan 29.
Motivated by experimental work (Miller et al. in Biomaterials 27(10):2213-2221, 2006, 32(11):2775-2785, 2011) we investigate the effect of growth factor driven haptotaxis and proliferation in a perfusion tissue engineering bioreactor, in which nutrient-rich culture medium is perfused through a 2D porous scaffold impregnated with growth factor and seeded with cells. We model these processes on the timescale of cell proliferation, which typically is of the order of days. While a quantitative representation of these phenomena requires more experimental data than is yet available, qualitative agreement with preliminary experimental studies (Miller et al. in Biomaterials 27(10):2213-2221, 2006) is obtained, and appears promising. The ultimate goal of such modeling is to ascertain initial conditions (growth factor distribution, initial cell seeding, etc.) that will lead to a final desired outcome.
受实验工作的启发（Miller 等人，Biomaterials 27(10):2213-2221, 2006;32(11):2775-2785, 2011），我们研究了在灌注组织工程生物反应器中，生长因子驱动的趋化性和增殖的影响，其中富含营养的培养基通过 2D 多孔支架灌注，该支架中浸渍有生长因子并接种了细胞。我们在细胞增殖的时间尺度上对这些过程进行建模，细胞增殖的时间尺度通常为数天。虽然这些现象的定量表示需要比目前可用的更多的实验数据，但与初步的实验研究（Miller 等人，Biomaterials 27(10):2213-2221, 2006）取得了定性的一致，这似乎很有希望。这种建模的最终目标是确定初始条件（生长因子分布、初始细胞接种等），这些条件将导致最终所需的结果。
