Mucin 2 免疫组化表达在结直肠癌中的临床病理意义：一项荟萃分析。
Clinicopathological Significance of Mucin 2 Immuno-histochemical Expression in Colorectal Cancer: A Meta-Analysis.
机构信息
Department of Pathology, Affiliated First Hospital, Nanjing Medical University, Nanjing 210006, China.
出版信息
Chin J Cancer Res. 2012 Sep;24(3):190-5. doi: 10.1007/s11670-012-0190-z.
OBJECTIVE
To evaluate the association between mucin 2 (MUC2) expression and clinicopathological characters of colorectal cancer.
METHODS
A literature search was performed on December 31, 2010 according to defined selection criteria. We evaluated the correlation between MUC2 (detected by immunohistochemistry) and clinicopathological characters of colorectal cancer. According to the tumor histological type, differentiation, location and TNM staging of colorectal carcinoma, we divided the clinicopathological characteristics into different subgroups. Fixed and random effects models were applied for estimation of the summarized risk ratios (RRs) and 95% confidence intervals (CIs) in different subgroups. Finally, forest plots and funnel plots were created to allow for visual comparison of the results or the effect of publication bias.
RESULTS
According with the inclusive criteria, fourteen studies (n=1,558) were eligible for the meta-analysis. We observed a trend towards a correlation of MUC2 higher positivity in mucinous than non-mucinous carcinoma (RR, 2.10; 95% CI, 1.30-3.40; P=0.002) and less positivity in distal than proximal colon (RR, 0.74; 95% CI, 0.64-0.85; P=0.000). There was no statistically significance for the association between MUC2 expression and differentiation or TNM staging of colorectal cancer, but MUC2 overexpression tended to be associated with the presence of T stage tumor (RR, 1.17; P=0.052).
CONCLUSION
MUC2 overexpression was associated with the mucinous and proximal colorectal cancer.
目的
评估黏蛋白 2（MUC2）表达与结直肠癌临床病理特征的关系。
方法
根据既定的选择标准，于 2010 年 12 月 31 日进行文献检索。我们评估了 MUC2（通过免疫组织化学检测）与结直肠癌临床病理特征之间的相关性。根据结直肠癌的组织学类型、分化程度、部位和 TNM 分期，我们将临床病理特征分为不同的亚组。应用固定效应模型和随机效应模型来估计不同亚组汇总的风险比（RR）及其 95%置信区间（CI）。最后，创建森林图和漏斗图，以便直观比较结果或发表偏倚的影响。
结果
根据纳入标准，共有 14 项研究（n=1558）符合荟萃分析的条件。我们观察到 MUC2 在黏液型癌中的阳性率高于非黏液型癌（RR，2.10；95%CI，1.30-3.40；P=0.002），而在远端结肠中的阳性率低于近端结肠（RR，0.74；95%CI，0.64-0.85；P=0.000），这种相关性呈趋势性。MUC2 表达与结直肠癌的分化程度或 TNM 分期之间无统计学意义，但 MUC2 过表达与 T 期肿瘤的存在呈正相关（RR，1.17；P=0.052）。
结论
MUC2 过表达与黏液型和近端结直肠癌相关。
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