Iwase Tsuyoshi, Kushima Ryoji, Mukaisho Ken-ichi, Mitsufuji Shoji, Okanoue Takeshi, Hattori Takanori
Department of Pathology, Shiga University of Medical Science, Seta-Tsukinowa-Cho, Ohtsu, Shiga, Japan.
Pathol Res Pract. 2005;201(2):83-91. doi: 10.1016/j.prp.2004.09.016.
There are two opposing theories of the natural history of colorectal neoplasm, adenoma-carcinoma sequence and de novo carcinogenesis. To elucidate the histogenesis of colorectal carcinoma, we investigated the expression of CD10, MUC2, MUC5AC, MUC6, and p53 in colorectal neoplasms. Sixty-seven morphologically distinct neoplastic specimens were divided into the following groups according to morphology: adenoma (groups A and B), protruded-type carcinoma (group C), superficial-type carcinoma with adenomatous component (group D), or superficial-type carcinomas without any adenomatous component (group E). Diagnoses of adenomas and carcinomas were based upon the Vienna classification of gastrointestinal epithelial neoplasia. The expression of CD10 in group E lesions was more intense than in the other groups. Regardless of morphology, MUC2 expression was significantly decreased in CD10-positive carcinomas, and the p53-positive rate was much higher in CD10-positive than in CD10-negative carcinomas. The overexpression of CD10 and reduced expression of MUC2 may be associated with the development and progression of colorectal carcinoma. A specific tendency was evident in superficial-type carcinomas without any adenomatous component (de novo carcinomas). These carcinomas are considered to be more aggressive than other morphologically distinct carcinomas.
关于结直肠肿瘤的自然史存在两种对立的理论，即腺瘤 - 癌序列和新发癌形成。为了阐明结直肠癌的组织发生，我们研究了结直肠肿瘤中CD10、MUC2、MUC5AC、MUC6和p53的表达。67个形态学上不同的肿瘤标本根据形态学分为以下几组：腺瘤（A组和B组）、隆起型癌（C组）、具有腺瘤成分的浅表型癌（D组）或无任何腺瘤成分的浅表型癌（E组）。腺瘤和癌的诊断基于胃肠道上皮肿瘤的维也纳分类。E组病变中CD10的表达比其他组更强烈。无论形态如何，CD10阳性癌中MUC2的表达均显著降低，且CD10阳性癌的p53阳性率远高于CD10阴性癌。CD10的过表达和MUC2的表达降低可能与结直肠癌的发生和发展有关。在无任何腺瘤成分的浅表型癌（新发癌）中存在一种特定趋势。这些癌被认为比其他形态学上不同的癌更具侵袭性。
