[Surgical treatment of hormone-induced recurrent and peptic ulcers of anastomosis].

The authors operated on 20 patients with the Zollinger-Ellison syndrome and on 3 patients with Wermer's syndrome. The clinical picture of the disease and the findings of laboratory tests and special methods of examination allow the Zollinger-Ellison syndrome to be diagnosed in most cases and a niveau diagnosis of gastrinoma to be established in some cases. Intraoperative ultrasonic examination is significant in making the niveau diagnosis. The authors claim that the operation of choice in the Zollinger-Ellison syndrome is total gastrectomy (extirpation of the gastric stump) with esophagojejunoduodenoplasty as well as one-stage removal of the revealed tumor by resection of the pancreas or enucleation of the tumor. The application of the group of H2-receptor blocking agents cannot be a substitute for operative treatment, but is expedient as a measure of preoperative management.