人类癌症中的DNA甲基化分析。
DNA methylation analysis in human cancer.
作者信息
O'Sullivan Eileen, Goggins Michael
机构信息
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
出版信息
Methods Mol Biol. 2013;980:131-56. doi: 10.1007/978-1-62703-287-2_7.
Abstract
The functional impact of aberrant DNA methylation and the widespread alterations in DNA methylation in cancer development have led to the development of a variety of methods to characterize the DNA methylation patterns. This chapter critiques and describes the major approaches to analyzing DNA methylation.
摘要
异常DNA甲基化的功能影响以及癌症发展过程中DNA甲基化的广泛改变，促使了多种用于表征DNA甲基化模式的方法的发展。本章对分析DNA甲基化的主要方法进行了评论和描述。
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