类风湿关节炎孕妇早产率高。
High rate of preterm birth in pregnancies complicated by rheumatoid arthritis.
机构信息
Department of Obstetrics and Gynecology, Stanford University, Stanford, California.
Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.
出版信息
Am J Perinatol. 2014 Jan;31(1):9-14. doi: 10.1055/s-0033-1333666. Epub 2013 Jan 28.
OBJECTIVE
To describe the outcomes of pregnancies complicated by rheumatoid arthritis (RA) and to estimate potential associations between disease characteristics and pregnancy outcomes.
STUDY DESIGN
We reviewed all pregnancies complicated by RA delivered at our institution from June 2001 through June 2009. Fisher exact tests were used to calculate odds ratios. Univariable regression was performed using STATA 10.1 (StataCorp, College Station, TX). A p value of ≤ 0.05 was considered statistically significant.
RESULTS
Forty-six pregnancies in 40 women were reviewed. Sixty percent of pregnancies had evidence of disease flare and 28% delivered prior to 37 weeks. We did not identify associations between preterm birth and active disease at conception or during pregnancy. In univariate analysis, discontinuation of medication because of pregnancy was associated with a significantly earlier gestational age at delivery (362/7 versus 383/7 weeks, p = 0.022).
CONCLUSION
Women with RA may be at higher risk for preterm delivery.
目的
描述类风湿关节炎（RA）合并妊娠的结局，并评估疾病特征与妊娠结局之间的潜在关联。
研究设计
我们回顾了 2001 年 6 月至 2009 年 6 月在我院分娩的所有合并 RA 的妊娠。采用 Fisher 确切检验计算比值比。采用 STATA 10.1（StataCorp，College Station，TX）进行单变量回归。p 值≤0.05 被认为具有统计学意义。
结果
共回顾了 40 名女性的 46 次妊娠。60%的妊娠有疾病活动的证据，28%的妊娠在 37 周前分娩。我们没有发现早产与妊娠前或妊娠期间的活动期疾病之间存在关联。单变量分析显示，因妊娠而停药与分娩时的妊娠周数明显更早相关（362/7 周与 383/7 周，p=0.022）。
结论
患有 RA 的女性可能有更高的早产风险。
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