[Changes in rheological properties of blood in patients with chronic glomerulonephritis].

The study of rheological blood properties in patients with chronic glomerulonephritis (CGN) demonstrates an increase in red blood cells aggregation and blood viscosity 3-4-fold while red blood cells deformability is two times less compared to healthy subjects. These findings well correlated with plasma fibrinogen and protein/lipid ratio of plasma and red blood cells. The highest informative value is associated with middle-sized and maximum-sized red blood cells aggregates which are significally related with a clinical form of the disease and its activity. The evidence obtained in the study is indicative of profound microcirculatory abnormalities in CGN patients necessitating administration of active antiaggregate therapy.