Craveri A, Tornaghi G, Paganardi L, Di Bella M, Gallo E, Stanzani M
Minerva Med. 1987 Jun 30;78(12):815-22.
Peripheral atherosclerotic arteriopathies are characterised by increased blood viscosity and, according to some, by a reduction in red blood cell deformability. Red blood cell viscosity was studied in 40 atherosclerosic patients (14 carotid and 26 aortoiliacofemoral lesions). All patients were subjected to the standard diagnostic examination (Doppler velocimetry, etc.). Fifty healthy non-smokers of the same sex and 20 heavy smokers were studied as controls. The viscosity of the whole blood, and plasma and blood fibrinogen were assayed. In studying erythrocyte viscosity, cells poor in leucocytes and platelets suspended in a saline phosphate buffer were employed. The atherosclerotic patients presented significantly higher mean levels of erythrocyte viscosity (p less than 0.01) and the increase in plasma viscosity and blood fibrinogen was also statistically significant. The viscosity of the whole blood was also increased in these patients (p less than 0.001). The increase in blood viscosity in subjects with peripheral arteriopathies therefore appears to be attributable to the plasma and to rheological alterations in the red blood cells.
外周动脉粥样硬化性血管病的特征是血液粘度增加，并且根据一些研究，还表现为红细胞变形能力降低。对40例动脉粥样硬化患者（14例颈动脉病变和26例主-髂-股动脉病变）的红细胞粘度进行了研究。所有患者均接受了标准诊断检查（多普勒测速等）。选取50名同性别的健康非吸烟者和20名重度吸烟者作为对照进行研究。测定了全血、血浆粘度及血纤维蛋白原含量。在研究红细胞粘度时，使用了悬浮于磷酸盐缓冲盐溶液中的白细胞和血小板含量较低的细胞。动脉粥样硬化患者的红细胞粘度平均水平显著更高（p<0.01），血浆粘度和血纤维蛋白原的升高也具有统计学意义。这些患者的全血粘度也有所增加（p<0.001）。因此，外周动脉病变患者血液粘度的增加似乎归因于血浆以及红细胞的流变学改变。
