Vorob'ev Iu I, Dmitrieva L A, Didenko V I, Belova N M, Spektor B M
Med Radiol (Mosk). 1990 Apr;35(4):16-20.
Morphological investigations under experimental conditions have demonstrated that local UHF-hyperthermia at 42-43 degrees C for 30 min does not cause alterative changes of the oral mucosa in animals. The revealed signs of activization of metabolic processes can probably increase radiosensitivity of tumors and their reparation. A favorable course of radiation mucositis was noted after experimental local hyperthermia and irradiation. Morphological changes of the oral mucosa, determined mainly by exposure to radiation, are characterized in the early period by alternative and dystrophic changes, and later on (in 3 mos.) by atrophy and sclerosis. In patients local UHF-hyperthermia had a radiosensitizing effect on the oral mucosa at 40-41,5 degrees C for 30 and 60 min. However it did not prevent the completion of a radical split course in the regimen of dynamic dose fractionation nor did it increase the number of postradiation complications. Under this temperature-time regimen the time of development and a degree of expression of radiation reactions did not depend on the succession of hyperthermia and irradiation, and the time of heating.
实验条件下的形态学研究表明，在42 - 43摄氏度局部超高频热疗30分钟不会引起动物口腔黏膜的变性改变。所揭示的代谢过程激活迹象可能会增加肿瘤的放射敏感性及其修复能力。实验性局部热疗和照射后，观察到放射性口腔黏膜炎病程良好。口腔黏膜的形态学变化主要由辐射暴露决定，早期表现为交替性和营养不良性变化，后期（3个月时）表现为萎缩和硬化。在患者中，40 - 41.5摄氏度局部超高频热疗30分钟和60分钟对口腔黏膜有放射增敏作用。然而，它并未阻止在动态剂量分割方案中完成根治性分割疗程，也未增加放疗后并发症的数量。在这种温度 - 时间方案下，放射反应的发生时间和表达程度不取决于热疗和照射的先后顺序以及加热时间。
