Poliakov P Iu, Karakulov R K, Pelevina I I, Zazovskiĭ L M, Dar'ialova S L
Med Radiol (Mosk). 1986 Dec;31(12):25-9.
Labeling index (LI) and growth fraction (GF) values were studied over time using biopsy specimens from patients with oropharyngeal cancer. The comparison of laboratory findings with tumor clinical response showed that a significant factor determining the tumor radiation reaction was the degree of LI and GF decrease during radiotherapy rather than their basal values. A favourable prognostic sign was a drop down to 0 or a sharp decrease in LI and GF values indicating a high tumor radiosensitivity, and enabling one to continue radiotherapy according to the radical program. A tumor could be considered radioresistant in case of an increase in LI and GF values by the end of an interval in the middle of a split course. In patients with resectable tumors treatment should end up with an operation; in those with unresectable tumors--it should be followed by combined radiotherapy, with an increased dose of interstitial gamma-therapy.
使用口咽癌患者的活检标本，对标记指数（LI）和生长分数（GF）值随时间进行了研究。实验室检查结果与肿瘤临床反应的比较表明，决定肿瘤放射反应的一个重要因素是放疗期间LI和GF下降的程度，而非其基础值。一个良好的预后迹象是LI和GF值降至0或急剧下降，这表明肿瘤具有高放射敏感性，并能使人们根据根治方案继续进行放疗。如果在分段疗程中间的一个间隔期结束时LI和GF值升高，则可认为肿瘤具有放射抗性。对于可切除肿瘤的患者，治疗应以手术结束；对于不可切除肿瘤的患者，应随后进行联合放疗，并增加间质γ治疗剂量。
