Department of Bioengineering & Department of Surgery, National University of Singapore, Singapore.
Microcirculation. 2013 Jul;20(5):440-53. doi: 10.1111/micc.12045.
To investigate how red blood cell aggregation could modulate the spatial variations in cell-free layer formation in the vicinity of an arteriolar bifurcation.
Visualization of blood flow was performed in upstream and downstream vessels of arteriolar bifurcations in the rat cremaster muscles under reduced flow conditions before and after induction of red blood cell aggregation to both physiological normal- and pathological hyperlevels seen in humans.
Large asymmetries of layer widths on opposite sides of the downstream vessel were attenuated along the vessel and this effect could be prominently enhanced by the hyperaggregation due to a higher formation rate of the layer which was greater on one side than the other of the vessel. The proportion of downstream layer formation constituted by the smaller downstream vessel generally increased with a thicker layer width at the wall of the upstream vessel adjacent it. A greater tendency of the layer formation in the smaller downstream vessel was found under the hyperaggregating condition than normal-aggregating and nonaggregating conditions.
Red blood cell aggregation could attenuate the asymmetry in cell-free layer formation on opposite sides of the downstream vessel, but enhances the heterogeneity of the layer formation between downstream vessels.
研究红细胞聚集如何调节动脉分支部附近无细胞层形成的空间变化。
在诱导红细胞聚集到生理正常和病理高值（如人类所见）前后，在降低血流条件下，在大鼠精索肌的动脉分支部上游和下游血管中观察血流可视化。
下游血管对侧层宽的大不对称性沿血管减弱，这种效应可以通过由于更高的层形成率而明显增强，层形成率在血管的一侧大于另一侧。由较小的下游血管构成的下游层形成的比例通常随着相邻上游血管壁的层宽度增加而增加。在高聚集状态下，下游血管中形成层的趋势大于正常聚集和非聚集状态。
红细胞聚集可以减轻下游血管对侧无细胞层形成的不对称性，但会增强下游血管之间层形成的异质性。
