Department of Dentistry, Taishan Sanatorium of Shandong Province, Taian, Shandong Province, China.
Curr Pharm Biotechnol. 2013;14(2):209-19.
Salmonella enterica is a Gram-negative intracellular bacterial pathogen which causes salmonellosis in humans and animals. During the past several decades, extensive studies have shown that the attenuated Salmonella vaccine vector is an optimal vehicle for delivering passenger antigens to mucosal sites to induce humoral, cellular, and mucosal immunity. This immunity leads to protection against challenges with the wild-type pathogens from which the passenger antigens were derived. A myriad of studies have demonstrated that using attenuated Salmonella vaccines for recombinant multivalent vaccine construction has multiple advantages. In this review, we summarize these advantages and further evaluate the Salmonella-based vaccines against five bacterial diseases. Four of these are Gram-negative pathogens- Escherichia coli, Helicobacter pylori, Shigella dysenteriae, and Yersinia pestis-and one is a mycobacterial pathogen, Mycobacterium tuberculosis. Apart from H. pylori, the Salmonella-based vaccines against the other four pathogens exhibit excellent performance in safety, immunogenicity, and protection. These properties qualify them to be as a new generation of vaccines for preventing infections from bacterial pathogens.
肠炎沙门氏菌是一种革兰氏阴性细胞内细菌病原体，可导致人类和动物的沙门氏菌病。在过去的几十年中，广泛的研究表明，减毒沙门氏菌疫苗载体是将乘客抗原递送至黏膜部位以诱导体液、细胞和黏膜免疫的最佳载体。这种免疫可防止来自乘客抗原来源的野生型病原体的挑战。无数研究表明，使用减毒沙门氏菌疫苗进行重组多价疫苗构建具有多种优势。在这篇综述中，我们总结了这些优势，并进一步评估了针对五种细菌性疾病的基于沙门氏菌的疫苗。其中四种是革兰氏阴性病原体-大肠杆菌、幽门螺杆菌、志贺氏菌和鼠疫耶尔森菌-一种是分枝杆菌病原体，结核分枝杆菌。除了幽门螺杆菌外，针对其他四种病原体的基于沙门氏菌的疫苗在安全性、免疫原性和保护方面表现出色。这些特性使它们有资格成为预防细菌病原体感染的新一代疫苗。
