The Biodesign Institute, Arizona State University, 1001 S. McAllister Avenue, Tempe, AZ 85287-5401, USA.
Expert Rev Vaccines. 2013 Sep;12(9):1033-45. doi: 10.1586/14760584.2013.825454.
Attenuated Salmonella vaccines can be administered orally to deliver recombinant antigens to mucosal surfaces inducing a protective immune response against a variety of targeted pathogens. A number of exciting new approaches and technologies for attenuated Salmonella vaccines have been developed recently. However, a disconnect remains between results obtained with mice in preclinical studies and results obtained in human clinical trials. This is due to an incomplete understanding of Salmonella Typhi interactions with human hosts and inadequate animal models available for study. In this review, the authors describe recent progress in identifying important differences underlying S. Typhi-host interactions, the development of novel approaches to vaccine design and six recent clinical trials evaluating Salmonella-vectored vaccines.
减毒沙门氏菌疫苗可经口服给予，将重组抗原递送至黏膜表面，诱导针对多种靶向病原体的保护性免疫应答。最近开发了许多用于减毒沙门氏菌疫苗的令人兴奋的新方法和技术。然而，在临床前研究中用小鼠获得的结果与在人体临床试验中获得的结果之间仍然存在脱节。这是由于对伤寒沙门氏菌与人宿主相互作用的理解不完整，以及可供研究的动物模型不足所致。在这篇综述中，作者描述了在鉴定伤寒沙门氏菌-宿主相互作用的重要差异、疫苗设计的新方法的发展以及最近评估沙门氏菌载体疫苗的六项临床试验方面的最新进展。
