Loureiro Rute, Mesquita Katia A, Oliveira Paulo J, Vega-Naredo Ignacio
CNC - Center for Neuroscience and Cell Biology, University of Coimbra. 3004-517 Coimbra, Portugal.
Recent Pat Endocr Metab Immune Drug Discov. 2013 May;7(2):102-14. doi: 10.2174/18722148113079990006.
Complete knowledge about the evolution of the carcinogenic process has to include cancer stem cells (CSCs), which are essential to understand tumor occurrence, recurrence, and also its reduction rate after radio- and/or chemotherapeutic treatments. Understanding CSCs physiology and metabolism may be crucial for the development of novel effective therapies. Therefore, being mitochondria an undeniable target for cancer therapy and a central hub in metabolism and cell and death decisions, it is essential to take this organelle into account and explore its actions and involvements in the context of CSCs physiology. In this review, we focus on recent patents and discoveries about mitochondrial bioenergetics and physiology of CSCs. A full understanding of the role of mitochondrial activity in CSCs and the creation of new strategies, methods and discoveries to support actual treatments with novel ones are of pivotal importance in order to ultimately eradicate cancer.
对致癌过程演变的全面了解必须涵盖癌症干细胞（CSCs），这对于理解肿瘤的发生、复发以及放化疗后的缓解率至关重要。了解癌症干细胞的生理学和代谢对于开发新型有效疗法可能至关重要。因此，鉴于线粒体是癌症治疗不可忽视的靶点以及代谢、细胞生死抉择的核心枢纽，必须考虑这个细胞器并探索其在癌症干细胞生理学背景下的作用和参与机制。在本综述中，我们聚焦于关于癌症干细胞线粒体生物能量学和生理学的最新专利与发现。充分理解线粒体活性在癌症干细胞中的作用，以及创建新的策略、方法和发现以用新方法支持现有治疗，对于最终根除癌症至关重要。
