Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland.
Psychol Med. 2013 Nov;43(11):2361-7. doi: 10.1017/S0033291713000032. Epub 2013 Jan 29.
Both low birthweight and high birthweight have been associated with an increased risk for schizophrenia and cognitive impairments in the general population. We assessed the association between birthweight and cognitive performance in persons with schizophrenia and their unaffected first-degree relatives.
We investigated a population-based family sample comprising persons with schizophrenia (n = 142) and their unaffected first-degree relatives (n = 277). Both patients and relatives were interviewed with the Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV) and a comprehensive neuropsychological test battery was administered. Information on birthweight was obtained from obstetric records. We used generalized estimating equation (GEE) models to investigate the effect of birthweight, as a continuous variable, on cognitive functioning, adjusting for within-family correlation and relevant covariates.
Both low birthweight and high birthweight were associated with lower performance in visuospatial reasoning, processing speed, set-shifting and verbal and visual working memory among persons with schizophrenia and their unaffected first-degree relatives compared to individuals with birthweight in the intermediate range. The group × birthweight interactions were non-significant.
Both low birthweight and high birthweight are associated with deficits in cognition later in life. Schizophrenia does not seem to modify the relationship between birthweight and cognition in families with schizophrenia.
低出生体重和高出生体重都与普通人群中精神分裂症和认知障碍的风险增加有关。我们评估了出生体重与精神分裂症患者及其未受影响的一级亲属认知表现之间的关系。
我们调查了一个基于人群的家族样本，包括精神分裂症患者（n=142）及其未受影响的一级亲属（n=277）。患者和亲属均接受了 DSM-IV 轴 I 障碍临床定式访谈（SCID-CV）的访谈，并进行了全面的神经心理学测试。出生体重信息从产科记录中获得。我们使用广义估计方程（GEE）模型，在调整了家庭内相关性和相关协变量后，以连续变量的形式研究出生体重对认知功能的影响。
与出生体重处于中等范围的个体相比，低出生体重和高出生体重都与精神分裂症患者及其未受影响的一级亲属的视空间推理、处理速度、转换灵活性以及言语和视觉工作记忆能力下降有关。组×出生体重的交互作用无统计学意义。
低出生体重和高出生体重都与成年后的认知缺陷有关。精神分裂症似乎并没有改变精神分裂症家族中出生体重与认知之间的关系。
