Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Arch Iran Med. 2013 Feb;16(2):64-7.
Liver transplantation is a treatment for patients who have acute liver failure (ALF). This study aims to evaluate the outcomes following liver transplantation in patients with ALF and compare them with cirrhotic patients who underwent liver transplantation.
This retrospective cross-sectional study was conducted at Shiraz Organ Transplant Center between June 2004 and March 2011 to evaluate the clinical presentation and underlying etiology of patients with ALF and their outcomes following liver transplantation.
Out of 750 patients who underwent liver transplants, 12 (8 males and 4 females) had a diagnosis of ALF. The cirrhotic group (control) consisted of 20 transplanted patients. ALF patients were younger with a mean age of 18.7 ± 12.9 years compared to 37.4 ± 13.6 years in the cirrhotic group (P = 0.001). In the ALF group, 5 (41.66%) underwent partial living related liver transplantation compared to 1 (5%) in the cirrhotic group (P = 0.018). There were significantly more early post-transplant complications observed among patients with ALF compared to the cirrhotic group (P = 0.002).
Liver transplantation is safe, effective and should be considered in patients diagnosed with ALF.
肝移植是治疗急性肝衰竭（ALF）患者的一种方法。本研究旨在评估 ALF 患者肝移植后的结果，并将其与接受肝移植的肝硬化患者进行比较。
这是一项回顾性的病例对照研究，于 2004 年 6 月至 2011 年 3 月在设拉子器官移植中心进行，旨在评估 ALF 患者的临床表现和潜在病因及其肝移植后的结果。
在接受肝移植的 750 名患者中，有 12 名（8 名男性和 4 名女性）被诊断为 ALF。肝硬化组（对照组）包括 20 名接受移植的患者。ALF 患者更年轻，平均年龄为 18.7 ± 12.9 岁，而肝硬化组为 37.4 ± 13.6 岁（P = 0.001）。在 ALF 组中，5 名（41.66%）患者接受了部分活体亲属供肝移植，而肝硬化组中只有 1 名（5%）患者接受了该手术（P = 0.018）。与肝硬化组相比，ALF 组患者在移植后早期出现更多的并发症（P = 0.002）。
肝移植是安全有效的，对于诊断为 ALF 的患者应考虑进行肝移植。
