Hematology and Oncology Research Center, Vali-Asr Hospital, Tehran University of Medical Science, Tehran, Iran.
Arch Iran Med. 2013 Feb;16(2):123-5.
Neuroendocrine tumors (NET) arise from neuroendocrine cells and are an exceedingly rare malignancy in the gallbladder. In this case report, a 52-year-old woman with complaints of episodic abdominal pain for two months prior was admitted to our hospital. She had no other signs and symptoms and her laboratory tests were within normal limits. Ultrasonography showed a broad-necked mass (26 × 12 mm) in the gallbladder for which she underwent laparoscopic cholecystectomy. The final pathological diagnosis was a high grade neuroendocrine carcinoma of the gallbladder with involvement of the lymph nodes and omentum. The patient received the chemotherapy regimens of gemcitabine plus cisplatin, followed by docetaxel plus sunitinib for her metastatic liver lesions. She also underwent radiofrequency ablation. Serial CT-scans revealed metastatic liver lesions that had decreased in size, with no significant improvement. The patient refused additional treatment and at 46 months, she was doing well with no complaints of any pain, disease recurrence, or metastatic progression.
神经内分泌肿瘤（NET）起源于神经内分泌细胞，在胆囊中极为罕见。本病例报告中，一名 52 岁女性因间歇性腹痛 2 个月就诊，无其他症状，实验室检查正常。超声检查显示胆囊内有一宽颈肿块（26×12mm），行腹腔镜胆囊切除术。最终病理诊断为胆囊高级别神经内分泌癌，伴有淋巴结和大网膜受累。患者接受了吉西他滨联合顺铂、多西他赛联合舒尼替尼治疗转移性肝病变，并进行了射频消融。连续 CT 扫描显示转移性肝病变的大小有所减小，但无明显改善。患者拒绝进一步治疗，46 个月后，患者无任何疼痛、疾病复发或转移进展的症状，情况良好。
