Corten Bartholomeus J G A, Leclercq Wouter K G, Dercksen M Wouter, van den Broek Wilhelmus T, van Zwam Peter H, Dejong Cees H, Slooter Gerrit D
Department of Surgery, Máxima Medical Center, Veldhoven, the Netherlands.
Department of Surgery, Máxima Medical Center, Veldhoven, the Netherlands.
Int J Surg Case Rep. 2019;65:205-208. doi: 10.1016/j.ijscr.2019.10.042. Epub 2019 Oct 28.
Neuroendocrine neoplasm of the gallbladder is an extremely uncommon diagnosis. We present a case of a benign gallbladder paraganglion that was initially incorrectly diagnosed as a neuroendocrine tumour (NET).
A 27-year-old female with symptomatic gallstone disease underwent an uncomplicated laparoscopic cholecystectomy. Routine histopathologic examination suggested the presence of a small adventitial NET. However, histopathological revision was performed by our pathologist because of regional gallbladder carcinoma (GBC) treatment evaluation. The revision demonstrated the presence of a normal paraganglion, a preexistent structure that is only rarely encountered during routine histopathologic examination of the gallbladder.
Neuroendocrine neoplasms of the gallbladder are extremely rare. Treatment varies from a simple cholecystectomy to extensive surgical resections. Chemotherapy is usually reserved for metastatic disease. In contrast, a gallbladder paraganglion is a benign entity not requiring additional treatment.
A neuroendocrine neoplasm of the gallbladder may closely resemble a benign paraganglion. If a NET is suspected, the clinician should be aware of the histopathologic mimicry of a paraganglion prior to initiating additional treatments.
胆囊神经内分泌肿瘤是一种极为罕见的诊断。我们报告一例最初被误诊为神经内分泌肿瘤（NET）的良性胆囊副神经节瘤病例。
一名患有症状性胆结石疾病的27岁女性接受了一次无并发症的腹腔镜胆囊切除术。常规组织病理学检查提示存在一个小的外膜神经内分泌肿瘤。然而，由于区域胆囊癌（GBC）治疗评估，我们的病理学家进行了组织病理学复查。复查显示存在一个正常的副神经节，这是一种在胆囊常规组织病理学检查中很少遇到的先前存在的结构。
胆囊神经内分泌肿瘤极为罕见。治疗方法从简单的胆囊切除术到广泛的手术切除不等。化疗通常用于转移性疾病。相比之下，胆囊副神经节瘤是一种良性实体，无需额外治疗。
胆囊神经内分泌肿瘤可能与良性副神经节瘤极为相似。如果怀疑是神经内分泌肿瘤，临床医生在开始额外治疗之前应意识到副神经节瘤的组织病理学模仿。
