Trent J M, Meyskens F L, Salmon S E, Ryschon K, Leong S P, Davis J R, McGee D L
Department of Medicine, University of Arizona, Tucson 85724.
N Engl J Med. 1990 May 24;322(21):1508-11. doi: 10.1056/NEJM199005243222107.
The value of chromosomal analysis is well established in human hematologic neoplasms. In contrast, the relation between chromosomal abnormalities and clinical outcome in solid tumors in humans has received little study. We undertook this study to determine whether chromosomal abnormalities could provide information on the survival of patients with malignant melanoma. Chromosome-banding analysis was performed on tumor-biopsy samples from 62 patients with metastatic melanoma, and recurring cytogenetic abnormalities were correlated with survival. Patients with structural abnormalities of chromosome 7 or 11 had significantly shorter survival than patients without these abnormalities. We conclude that cytogenetic analysis may provide useful prognostic information about patients with metastatic melanoma.
染色体分析在人类血液系统肿瘤中的价值已得到充分证实。相比之下，人类实体瘤中染色体异常与临床结局之间的关系却鲜有研究。我们开展这项研究以确定染色体异常是否能为恶性黑色素瘤患者的生存情况提供信息。对62例转移性黑色素瘤患者的肿瘤活检样本进行了染色体显带分析，并将反复出现的细胞遗传学异常与生存情况相关联。7号或11号染色体结构异常的患者的生存期明显短于无这些异常的患者。我们得出结论，细胞遗传学分析可能为转移性黑色素瘤患者提供有用的预后信息。
