Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Int J Gynecol Cancer. 2013 Mar;23(3):456-60. doi: 10.1097/IGC.0b013e318284aafe.
The Saudi population is characterized by high parity and intermarriages that may impact ovarian carcinogenesis. Herein, we analyzed the tumor characteristics and outcomes in Saudi patients with epithelial ovarian cancer (EOC).
Patients with EOC treated at King Faisal Specialist Hospital and Research Center during 1995-2007 were identified retrospectively through a review of their medical records. Patients' and tumor characteristics were collected including age at diagnosis, marital status, parity, histology, stage, treatment rendered, and follow-up data.
One hundred-ninety-three patients with EOC were identified in this cohort. The mean age of the patients was 55 ± 15 years, the mean ± SD body mass index was 27.0 ± 5.6 kg/m, and the median parity was approximately 7.0. Whereas 4 patients reported a family history of cancer, 164 women reported negative family history; and it was unknown in 27 cases. Tumor distribution by International Federation of Gynecology and Obstetrics stage was the following: 12 patients (6.2%) had stage I disease at diagnosis, 1 patient (0.5%) stage II disease, 130 patients (67.4%) stage III disease, 39 patients (20.2%) stage IV disease, and that of 11 patients (5.7%) was unknown. Information on residual disease after surgery was available on 98 patients with optimal debulking (<1 cm) achieved in 61 cases. Median progression-free survival from end of chemotherapy to recurrence/progression was 11.9 months (95% confidence interval, 9.4-15.2). Tumor histology, size of residual disease, and stage at diagnosis were significant prognostic factors. The patients' age, body mass index, tumor histology, and grade had no impact on survival.
Patients presenting with advanced-stage disease are higher among Saudis than those reported in global literature. Despite high intermarriage rates, reported family history for related cancers was quite low in this cohort. Notably, this is the first study evaluating EOC in Saudi patients.
沙特人口的特点是高生育率和跨国婚姻，这可能会影响卵巢癌的发生。在此，我们分析了沙特上皮性卵巢癌（EOC）患者的肿瘤特征和结局。
通过回顾病历，回顾性地确定了 1995 年至 2007 年期间在法赫德国王专科医院和研究中心接受治疗的上皮性卵巢癌患者。收集了患者和肿瘤特征，包括诊断时的年龄、婚姻状况、生育史、组织学、分期、治疗方法和随访数据。
本队列共确定了 193 例上皮性卵巢癌患者。患者的平均年龄为 55±15 岁，平均±SD 体重指数为 27.0±5.6kg/m，中位数生育史约为 7.0。4 例患者报告有癌症家族史，164 例患者报告无家族史；27 例情况未知。国际妇产科联合会（FIGO）分期的肿瘤分布如下：12 例（6.2%）患者诊断时为 I 期疾病，1 例（0.5%）为 II 期疾病，130 例（67.4%）为 III 期疾病，39 例（20.2%）为 IV 期疾病，11 例（5.7%）情况未知。98 例接受最佳减瘤术（＜1cm）的患者中，有 61 例获得了残余疾病的信息。从化疗结束到复发/进展的中位无进展生存期为 11.9 个月（95%置信区间，9.4-15.2）。肿瘤组织学、残余疾病大小和诊断时的分期是显著的预后因素。患者的年龄、体重指数、肿瘤组织学和分级对生存没有影响。
与全球文献报道相比，沙特患者就诊时疾病分期更高。尽管跨国婚姻率较高，但在本队列中，报告的相关癌症家族史相当低。值得注意的是，这是第一项评估沙特患者上皮性卵巢癌的研究。
